Northwestern University Feinberg School of Medicine
Feinberg Cardiovascular Research Institute
Paul W Burridge, PhD

Paul W Burridge, PhD

Assistant Professor of Pharmacology

Contact

312-503-4895

Searle Building Room 8-525
320 E Superior
Chicago IL 60611

paul.burridge( at )northwestern.edu

Education/Research Website

Education and Certification

PhD: University of Nottingham, UK, Stem Cell Biology (2008)

Interests

Description of Interests

We study the application of patient-specific human induced pluripotent stem cells in studying the role of the genome in influencing drug responses, a field known as pharmacogenomics or personalized me... read more
We study the application of patient-specific human induced pluripotent stem cells in studying the role of the genome in influencing drug responses, a field known as pharmacogenomics or personalized medicine. Our major effort has been focused on patient-specific responses to chemotherapy agents. We ask the question: what is the genetic reason why some patients have minimal side effects of their cancer treatments, whilst others encounter highly detrimental side effects? These side effects can include cardiomyopathy (heart failure or arrhythmias), peripheral neuropathy, or hepatotoxicity (liver failure). It is our aim to add to risk-based screening by functionally validating genetic changes that predispose a patient to a specific drug response. We use a combination of next-generation sequencing, automation and robotics, high-throughput drug screening, high-content imaging, tissue engineering, and electrophysiological testing to better understand the mechanisms of drug response and action.

Interests (Keywords)

Adverse Drug Reactions; Bioengineering; Bioinformatics; Breast Cancer; Cardiology; Drug Discovery; Regenerative Medicine; Stem Cells

Research and Publications

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