Northwestern University Feinberg School of Medicine
Feinberg Cardiovascular Research Institute
William A Muller, MD, PhD

William A Muller, MD, PhD

Magerstadt Professor of Pathology

Professor of Pathology



Ward Building Room 3-140
303 E Chicago Avenue
Chicago IL 60611

wamuller( at )

Hospital Affiliations

I am on the medical staff at the following Feinberg-affiliated hospital(s)

Education and Certification

PhD: Rockefeller U (1981)
MD: Cornell U Medical Ca (1982)
Internship: Massachusetts General Hospital (1983)
Residency: Brigham & Women's Hospital (1987)
Board Certification: Anatomic Pathology


Description of Interests

My lab studies the inflammatory response at the cellular and molecular level. We are focused on the process of diapedesis, the "point of no return" in inflammation where leukocytes squeeze between tightly apposed endothelial cells to enter the site of inflammation. We have identified and cloned several molecules that are critical to the process of diapedesis (PECAM (CD31), CD99, and VE-cadherin) and are studying how they regulate the inflammatory response using in vitro and in vivo models. We have recently described the Lateral Border Recycling Compartment, a novel para-junctional organelle that contains PECAM and CD99 and is critical for diapedesis to occur. We are currently investigating how this compartment regulates diapedesis in the hope of finding novel targets for anti-inflammatory therapy.

Interests (Keywords)

Cell Adhesion Mechanisms; Cell Imaging; Immune System; Inflammation; Leukocyte-endothelial cell interactions; Multiple Sclerosis; Pathology; Vascular Biology

Research and Publications

Northwestern Scholars

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